P. Wu

The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.

This study identifies SARS-CoV-2 host targets and perturbed proteins in PBMCs from COVID-19 patients, revealing potential virulence factors involved in cytokine storms and disease pathogenesis.

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

This paper introduces FucoID, a method to detect and isolate tumor-specific antigen-reactive T cells from tumor-infiltrating lymphocytes using fucosyl-biotinylation, revealing distinct gene features and functional capabilities.

This study develops a live cell assay using hFUT1 to profile α1-2-fucosides' role in enhancing influenza A virus infection.

This paper uses single-cell RNA sequencing to characterize neutrophil heterogeneity and maturation during homeostasis and bacterial infection, revealing distinct subsets and their functional transitions.

This study shows that fucosylation of N-glycans modulates Wnt signaling by affecting LRP6 endocytosis, revealing a new glycosylation-dependent regulatory mechanism.

The paper develops a single-step fluorescent glycan labeling method to image sialylation and fucosylation in live zebrafish embryos, revealing their roles in hematopoiesis.

This paper introduces a microfluidic chip that improves single-cell encapsulation efficiency by fourfold, achieving a 3% co-capturing rate with low doublet rates in sequencing data.

This paper designs multi-furcating microfluidic channels for efficient droplet splitting and investigates splitting regimes and breakup mechanisms.

This study evaluates fusidic acid and its hydrogenation derivative for antimicrobial and anti-inflammatory effects against Gram-positive bacteria and in a mouse model.

The paper integrates CPTAC proteomics data into cBioPortal to enable integrative analysis with genomics and clinical data from the same tumors.