Author

D. G. Chapla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:zebrafish· 1

Frequent Co-Authors

K. W. Moremen· 4 shared P. Wu· 4 shared S. Hong· 4 shared C. Yu· 3 shared J. C. Paulson· 2 shared M. S. Macauley· 2 shared N. Reigh· 2 shared P. Wang· 2 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiochemistry

K. W. Moremen

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Author profile →

4 papers

Recent·Most cited

Modulation of Siglec-7 Signaling via in situ Created High-affinity cis-Ligands

S. Hong, C. Yu, Y. Shi, P. Wang, D. G. Chapla, E. Rodrigues, K. W. Moremen, J. C. Paulson, M. S. Macauley, P. Wu

The paper shows that modulating Siglec-7 signaling via high-affinity cis-ligands on NK cells can suppress or enhance NK cytotoxicity depending on ligand concentration.

bioRxiv · Jul 15, 2020 · PreprintBiochemistry

Glycoengineering of NK cells with glycan ligands of CD22 and selectins for B-cell lymphoma therapy

S. Hong, C. Yu, P. Wang, Y. Shi, B. Cheng, M. CHEN, D. G. Chapla, N. Reigh, Y. Narimatsu, X. Chen, H. Clausen, K. W. Moremen, M. S. Macauley, J. C. Paulson, P. Wu

This study modifies NK cells with CD22 and selectin glycan ligands to enhance B-cell lymphoma targeting and trafficking, achieving effective tumor suppression in a xenograft model.

bioRxiv · Mar 23, 2020Bioengineering

hFUT1-based live cell assay to profile α1-2-fucosides enhanced influenza A virus infection

S. Hong, G. Grande, C. Yu, D. G. Chapla, N. Reigh, Y. Yang, K. Izumori, K. W. Moremen, J. Xie, P. Wu

This study develops a live cell assay using hFUT1 to profile α1-2-fucosides' role in enhancing influenza A virus infection.

bioRxiv · Nov 25, 2019Biochemistry

Direct Visualization of Live Zebrafish Glycan via Single-step Metabolic Labeling with Fluorophore-tagged Nucleotide Sugars

S. Hong, P. Sahai-Hernandez, D. G. Chapla, K. W. Moremen, D. Traver, P. Wu

The paper develops a single-step fluorescent glycan labeling method to image sialylation and fucosylation in live zebrafish embryos, revealing their roles in hematopoiesis.

bioRxiv · Jun 20, 2019Biochemistry