Enhancing the anti-tumor efficacy of Bispecific T cell engagers via cell surface glycocalyx editing
Z. Yang, G. Grande, Y. Hou, C. Wang, Y. Shi, J. Zak, J. H. Cho, D. Liu, J. Teijaro, R. A. Lerner, P. Wu
This study develops BiTE-sialidase fusion proteins that enhance anti-tumor efficacy by desialylating tumor cells, improving T-cell activation and cytolysis in vitro and in vivo.
bioRxiv · May 22, 2022 · PreprintCancer Biology