P. Zorlutuna

Adult Human Heart ECM Improves Human iPSC-CM Function via Mitochondrial and Metabolic Maturation

This study shows that adult human heart ECM improves iPSC-derived cardiomyocytes' function through mitochondrial and metabolic maturation.

Aged Breast Matrix Bound Vesicles Promote Breast Cancer Invasiveness

This study identifies aged breast matrix-bound vesicles (MBVs) that promote cancer invasiveness by altering miRNA and cytokine profiles in human mammary epithelial cells.

In Need of Age-Appropriate Cardiac Models: Impact of Cell Age on Extracellular Matrix Therapy Outcomes

This study shows that cell age affects the outcomes of extracellular matrix therapy in cardiac models, highlighting the need for age-matched human iCMs in research.

Maternal obesity driven changes in collagen linearity of breast extracellular matrix induces invasive mammary epithelial cell phenotype

This study shows that maternal obesity alters breast extracellular matrix collagen structure, increasing mammary epithelial cell migration and invasion.

Age and Sex-Dependent Differences in Human Cardiac Matrix-Bound Exosomes Modulate Fibrosis through Synergistic miRNA Effects

This study identifies age and sex differences in cardiac matrix-bound exosomes and shows their synergistic miRNA effects on fibrosis.

Circulatory systems and mortality rates

The paper develops two models to explain the diversity of aging across lifeforms by examining connectivity structures and biophysical transport mechanisms.

Tunable human myocardium derived decellularized extracellular matrix for 3D bioprinting and cardiac tissue engineering

This paper develops tunable bioinks using decellularized human myocardium ECM for 3D bioprinting, showing improved mechanical properties and cardiac tissue-like behavior.

Aged Breast Extracellular Matrix Drives Mammary Epithelial Cells to an Invasive and Cancer-Like Phenotype

This study shows that aged breast ECM drives mammary epithelial cells to an invasive, cancer-like phenotype through mechanisms involving EMT and LOX.

Effect of Cellular and ECM Aging on Human iPSC-derived Cardiomyocyte Performance, Maturity and Senescence

This study examines how cellular and ECM aging affect iPSC-derived cardiomyocyte function, maturity, and stress response, finding that ECM aging accelerates cellular aging and impairs cardiac function.

Tissue failure propagation as mediated by circulatory flow

The paper investigates how cell failure propagates in synthetic tissues under advective flow, finding analytical expressions for propagation dynamics.

Persistent cell motility requires transcriptional feedback of cytoskeletal - focal adhesion equilibrium by YAP/TAZ

The paper shows that YAP/TAZ transcriptional feedback is essential for maintaining cytoskeletal-focal adhesion equilibrium and persistent cell motility.

An aged human heart tissue model showing age-related molecular and functional deterioration resembling the native heart

This paper develops an in vitro aged human heart tissue model using hiPSC-derived cardiomyocytes to study age-related molecular and functional deterioration in cardiovascular disease.

Interdependence Theory of Tissue Failure: Bulk and Boundary Effects

This study presents a theoretical framework explaining how cellular-level damage accumulates and spreads in tissues, showing that intercellular interactions are critical to aging.