P.-W. Hu

Lysosome Lipid Signaling from the Periphery to Neurons Regulates Longevity

This study identifies a lysosomal lipid signaling pathway from fat to neurons in C. elegans that promotes longevity by regulating neuropeptide signaling.

Lysosomal nucleotide metabolism regulates ER proteostasis through mTOR signaling

This study identifies RSH-1 as a lysosomal NADPH phosphatase that regulates ER proteostasis via mTOR signaling in C. elegans.