Author

Y.-T. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. C. Wang· 2 shared M. Savini· 2 shared A. Ayoub· 1 shared A. Folick· 1 shared D. C. Neujahr· 1 shared D. P. Jones· 1 shared E. Ko· 1 shared E. Ortlund· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

M. C. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mitochondrial GTP Metabolism Regulates Reproductive Aging

Y.-T. Lee, M. Savini, T. Chen, J. Yang, Q. Zhao, L. Ding, S. M. Gao, M. Senturk, J. Sowa, J. D. Wang, M. C. Wang

This study shows that mitochondrial GTP metabolism regulates reproductive aging in C. elegans by controlling mitochondrial dynamics and homeostasis.

bioRxiv · Apr 2, 2023 · PreprintCell Biology

Lysosome Lipid Signaling from the Periphery to Neurons Regulates Longevity

M. Savini, J. D. Duffy, A. Folick, Y.-T. Lee, P.-W. Hu, I. Neve, F. Jin, Q. Zhang, M. Tillman, Y. Ye, W. Mair, J. Wang, L. Han, E. Ortlund, M. C. Wang

This study identifies a lysosomal lipid signaling pathway from fat to neurons in C. elegans that promotes longevity by regulating neuropeptide signaling.

bioRxiv · Jun 10, 2021 · PreprintCell Biology

MLL1 Methyltransferase Activity is Regulated by Distinct Nucleosome Binding Modes

A. Ayoub, S. H. Park, Y.-t. Lee, U.-S. Cho, Y. Dou

The paper determines the cryoEM structure of the MLL1 complex bound to a nucleosome and identifies two binding modes, one of which is catalytically inactive.

bioRxiv · Apr 13, 2021Biochemistry

Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice

J. D. Chandler, X. Hu, E. Ko, S. Park, J. Fernandes, Y.-T. Lee, M. L. Orr, L. Hao, M. R. Smith, D. C. Neujahr, K. Uppal, S.-M. Kang, D. P. Jones, Y.-M. Go

This study shows that low-dose cadmium exposure in mice increases lung inflammation and genetic responses to H1N1 influenza virus infection.

bioRxiv · Nov 15, 2018Pharmacology & Toxicology