P.-Y. Lozach

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF-κB signaling

A high-content RNA-based imaging assay reveals integrin beta 1 as a cofactor for cell entry of non-enveloped hepatitis E virus

This study identifies integrin beta 1 as a cofactor for naked hepatitis E virus entry, revealing distinct endocytic pathways for naked and enveloped HEV particles.

The phenuivirus Toscana virus makes an atypical use of vacuolar acidity to enter host cells

This study identifies Toscana virus as a late-penetrating virus that uses vacuolar acidity for entry, with an optimal fusion pH of 5.5 and infectious particles remaining viable below this threshold.

The glycolipid GlcCer is recruited into the viral envelope to promote phenuivirus binding to host cells

This study identifies GlcCer as a viral glycolipid essential for phenuivirus binding to host cells, showing its role in viral attachment and receptor identification.

Host Cell Proteases Drive Early or Late SARS-CoV-2 Penetration

This study investigates how SARS-CoV-2 uses different host cell proteases for entry, showing that TMPRSS2 enables rapid entry while cathepsin L and low pH are required in its absence.