Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response
Sarah J. Skuli, A’ishah Bakayoko, Marisa Kruidenier, Bryan Manning, Paige Pammer, Akmal Salimov, Owen Riley, Gisela Brake-Sillá, Derrick L. Dopkin, Michael Bowman, Leslie N. Martinez-Gutierrez, Colin C. Anderson, Julie A. Reisz, Roberta Buono, Madhuri Paul, , Martin P Carroll
This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.
Leukemia · Jul 9, 2025Peer-reviewedCancer Biology