Author

Brian Keith

Abramson Cancer CenterORCID 0000-0002-4853-0815Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Brian Keith2 papers · University of Pennsylvania

Biology Disciplines

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Cancer Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

A’ishah Bakayoko· 1 shared Akmal SalimoviD· 1 shared Andrew Matthews· 1 shared Angelo D’AlessandroiD· 1 shared Ann DevineiD· 1 shared Biliang HuiD· 1 shared Bryan Manning· 1 shared Carl H. JuneiD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A’ishah Bakayoko

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2 papers

Recent·Most cited

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

Sarah J. Skuli, A’ishah Bakayoko, Marisa Kruidenier, Bryan Manning, Paige Pammer, Akmal Salimov, Owen Riley, Gisela Brake-Sillá, Derrick L. Dopkin, Michael Bowman, Leslie N. Martinez-Gutierrez, Colin C. Anderson, Julie A. Reisz, Roberta Buono, Madhuri Paul, , Martin P Carroll

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

Leukemia · Jul 9, 2025Peer-reviewedCancer Biology

CAR T Cells Secreting IL18 Augment Antitumor Immunity and Increase T Cell Proliferation and Costimulation

Biliang Hu, Jiangtao Ren, Yanping Luo, Brian Keith, Regina M. Young, John Scholler, Yangbing Zhao, Carl H. June

This study shows that IL18-expressing CAR T cells enhance antitumor immunity, T cell proliferation, and costimulation, while reducing GVHD risk through a novel strategy.

Cell Reports · Sep 1, 2017Peer-reviewedSynthetic Biology