Peroxisomal Dysfunction Drives Loss of Dynamic Nutrient Responses to Initiate Metabolic Inflexibility During Aging
Arpit Sharma, Meeta Mistry, Pallas Yao, Yanshan Liang, Sheng Tony Hui, William B. Mair
This study shows that peroxisomal dysfunction during aging reduces metabolic flexibility by impairing mitochondrial dynamics and nutrient responses, which can be mitigated by dietary restriction.
bioRxiv · Feb 14, 2025 · PreprintCell Biology