Meeta Mistry

This study identifies 196 upregulated and 62 downregulated aging genes across long-lived C. elegans mutants, revealing distinct gene expression strategies for longevity.

This study shows that local IFNγ signaling in aged lungs impairs alveolar progenitor cell regeneration, and reducing IFNγ levels restores regenerative capacity.

This study shows that peroxisomal dysfunction during aging reduces metabolic flexibility by impairing mitochondrial dynamics and nutrient responses, which can be mitigated by dietary restriction.

The paper examines nine long-lived C. elegans mutants to show a strong correlation between stress resistance and longevity, driven by overlapping genetic pathways.

The paper shows that early life activity of RNA splicing factors and lipid metabolism determine the efficacy of longevity interventions in C. elegans.

This study shows that ATFS-1 activates multiple stress response pathways to increase resistance to exogenous stressors but reduces lifespan when chronically active.