Yanshan Liang

The paper links lower plasma plasmalogen levels to increased risk of lymph node positive breast cancer in humans and mice, showing dietary PUFA depletion promotes cancer survival in lymph nodes.

This study identifies sustained glucose turnover flux as a distinguishing metabolic feature of cancer cachexia compared to nutrient limitation under controlled food intake.

This study investigates the extent to which anorexia contributes to different cachectic phenotypes in cancer cachexia using a preclinical model.

The paper develops an organism-level quantitative flux model of energy metabolism in mice by integrating isotope tracing and mass spectrometry, revealing distinct metabolic cycling and oxidation flux patterns for circulating nutrients.

This study shows that peroxisomal dysfunction during aging reduces metabolic flexibility by impairing mitochondrial dynamics and nutrient responses, which can be mitigated by dietary restriction.