Functional selection in SH3-mediated activation of the PI3 kinase
Safia Aljedani, Anandsukeerthi Sandholu, Abdullah Aldehaiman, Siba Alharbi, Victor C. Y. Mak, Haiyan Wu, Panpan Wang, Afaque A. Momin, Upendra Singh, Adrien Lugari, Łukasz Jaremko, Mariusz Jaremko, Xavier Morelli, Jonathan Backer, John Edward Ladbury, , Stefan T. Arold
This study identifies how SH3 domains activate PI3K by engaging in tertiary interactions with p85, revealing a mechanism for controlling activation through functional selection.
Communications Biology · Jan 19, 2026Peer-reviewedBiochemistry