Development of a p62 biodegrader for autophagy targeted degradation
Zacharias Thiel, David Marcellin, Carole Manneville, Benedikt Goretzki, Luca Egger, Rob Maher, Noémie Siccardi, Laura Torres, Alexandra Probst, Catrin Swantje Müller, Nathalie George, Markus Vogel, Sabine Sinterhauf, Alexandra Lavoisier, Ji‐Young Choi, , Beat Nyfeler
The paper develops a p62-based biodegrader that selectively degrades mitochondria via autophagy but not cytosolic proteins due to its effect on p62 self-oligomerization.
Nature Communications · Dec 3, 2025Peer-reviewedSynthetic Biology