Author

Patty Sachamitr

Hospital for Sick Children

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

C.H. ArrowsmithiD· 2 shared Gary D. BaderiD· 2 shared Michelle M. KushidaiD· 2 shared Panagiotis PrinosiD· 2 shared Peter B. DirksiD· 2 shared Trevor J. PughiD· 2 shared Aiden M. Sababi· 1 shared Costanza Ferrari BardileiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

C.H. ArrowsmithORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Glioblastoma stem cells show transcriptionally correlated spatial organization

Shamini Ayyadhury, Patty Sachamitr, Michelle M. Kushida, Nicole Park, Fiona J. Coutinho, Owen Whitley, Panagiotis Prinos, C.H. Arrowsmith, Peter B. Dirks, Trevor J. Pugh, Gary D. Bader

The paper shows that glioblastoma stem cells form spatial patterns correlated with their transcriptional state, using image analysis to link morphology and gene expression.

Communications Biology · Jan 23, 2026Peer-reviewedCancer Biology

PRMT5 is required for full-length HTT expression by repressing multiple proximal intronic polyadenylation sites

Mona Alqazzaz, Felipe E. Ciamponi, Jolene Caifeng Ho, Maxim I. Maron, Manisha Yadav, Aiden M. Sababi, Graham Dickson and Hugh MacLeod, Moloud Ahmadi, Garrett Bullivant, Vincent Tano, Sarah R. Langley, María Sánchez‐Osuna, Patty Sachamitr, Michelle M. Kushida, Laura M. Richards, , Panagiotis Prinos

This paper identifies PRMT5 as a regulator of HTT mRNA splicing and alternative polyadenylation, showing that its inhibition reduces full-length HTT protein levels by promoting premature termination and cleavage.

bioRxiv · Mar 14, 2024 · PreprintNeuroscience