Author

Manisha Yadav

University Health Network

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:multiome· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Mahmoud A. PouladiiD· 2 shared Rachel HardingiD· 2 shared A.M. EdwardsiD· 1 shared Aiden M. Sababi· 1 shared Brandon A. Keith· 1 shared C.H. ArrowsmithiD· 1 shared Costanza Ferrari BardileiD· 1 shared Dalia Baršytė-LovejoyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Mahmoud A. PouladiORCID

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2 papers

Recent·Most cited

High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of Huntingtin

Esther Wolf, Rebeka Cataldo de Oliveira Fanti, Tatsuya Ikenoue, Justin C. Deme, Swati Balakrishnan, Brandon A. Keith, Matthew G. Alteen, Renu Chandrasekaran, Manisha Yadav, Ritika Bhajiawala, Suzanne Z. Ackloo, Feng Jia, Mahmoud A. Pouladi, A.M. Edwards, Derek J. Wilson, , Rachel Harding

This paper identifies and characterizes high-affinity, selective macrocyclic peptide ligands for Huntingtin, enabling structural and functional studies of HTT and its complex with HAP40.

bioRxiv · Aug 6, 2025 · PreprintBiochemistry

PRMT5 is required for full-length HTT expression by repressing multiple proximal intronic polyadenylation sites

Mona Alqazzaz, Felipe E. Ciamponi, Jolene Caifeng Ho, Maxim I. Maron, Manisha Yadav, Aiden M. Sababi, Graham Dickson and Hugh MacLeod, Moloud Ahmadi, Garrett Bullivant, Vincent Tano, Sarah R. Langley, María Sánchez‐Osuna, Patty Sachamitr, Michelle M. Kushida, Laura M. Richards, , Panagiotis Prinos

This paper identifies PRMT5 as a regulator of HTT mRNA splicing and alternative polyadenylation, showing that its inhibition reduces full-length HTT protein levels by promoting premature termination and cleavage.

bioRxiv · Mar 14, 2024 · PreprintNeuroscience