On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions
Linda Julian, Lisa Crozier, Devon A. Lukow, Sanat Mishra, Aditi Swamy, Ryan A. Hagenson, Peter C. Sennhenn, Erin L. Sausville, Brianna E. Mendelson, Claudio Chuaqui, Lu Qiao, Anand Vasudevan, Kuan‐Ting Lin, Sonam Bhatia, Thierry Bertomeu, , Jason M. Sheltzer
This study shows CDK11 is critical for cancer cell survival and identifies 1p36 deletions as a biomarker for CDK11 inhibitor sensitivity, but on-target toxicity limits therapeutic efficacy.
bioRxiv · Aug 3, 2025 · PreprintCancer Biology