Author

Brianna E. Mendelson

Yale UniversityORCID 0000-0002-1844-3198Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Aditi Swamy· 1 shared Adrian R. KraineriD· 1 shared Anand VasudevaniD· 1 shared Andrew Chatr‐aryamontriiD· 1 shared Claudio Chuaqui· 1 shared David L. SpectoriD· 1 shared Devon A. LukowiD· 1 shared Erin L. SausvilleiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Aditi Swamy

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions

Linda Julian, Lisa Crozier, Devon A. Lukow, Sanat Mishra, Aditi Swamy, Ryan A. Hagenson, Peter C. Sennhenn, Erin L. Sausville, Brianna E. Mendelson, Claudio Chuaqui, Lu Qiao, Anand Vasudevan, Kuan‐Ting Lin, Sonam Bhatia, Thierry Bertomeu, , Jason M. Sheltzer

This study shows CDK11 is critical for cancer cell survival and identifies 1p36 deletions as a biomarker for CDK11 inhibitor sensitivity, but on-target toxicity limits therapeutic efficacy.

bioRxiv · Aug 3, 2025 · PreprintCancer Biology