Author

James I. MacDonald

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Amanda R. GravelineiD· 1 shared Andyna VernetiD· 1 shared Catherine J. WuiD· 1 shared Chad Kelawan· 1 shared Christopher M. WintersingeriD· 1 shared Daniel T. PassosiD· 1 shared David J. MooneyiD· 1 shared Derin B. KeskiniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperSynthetic Biology

Amanda R. GravelineORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

WNT8B and -9B promote the survival and dissemination of dormant ovarian cancer cells

Komila Zakirova, Daniel T. Passos, Chad Kelawan, Michael V. Roes, Rizwan Tahir, Malcolm Hill, Seung J. Kim, Matthew J. Cecchini, Marco Mura, Trevor G. Shepherd, Pirunthan Perampalam, James I. MacDonald, Frederick A. Dick

This study identifies WNT8B and WNT9B as critical for ovarian cancer cell survival and dissemination during dormancy, showing their inhibition could improve treatment outcomes.

bioRxiv · Aug 11, 2026 · PreprintCancer Biology

Fine tuning of CpG spatial distribution with DNA origami for improved therapeutic cancer vaccination

Yang C. Zeng, Olivia J. Young, Christopher M. Wintersinger, Frances M. Anastassacos, James I. MacDonald, Giorgia Isinelli, Maxence O. Dellacherie, Miguel C. Sobral, Haiqing Bai, Amanda R. Graveline, Andyna Vernet, Melinda Sanchez, Kathleen Mulligan, Young–Jin Choi, Thomas C. Ferrante, , William M. Shih

This study developed a DNA origami-based cancer vaccine that co-delivers antigen and CpG immune adjuvant with an optimal nanospacing for Th1 immune polarization.

bioRxiv · Jun 8, 2022 · PreprintSynthetic Biology