Author

Frederick A. Dick

Western UniversityORCID 0000-0002-0047-9985Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Pirunthan Perampalam· 3 shared Arturo Bujarrabal-DuesoiD· 1 shared Björn SchumacheriD· 1 shared Chad Kelawan· 1 shared Daniel T. PassosiD· 1 shared David H. MeyeriD· 1 shared James I. MacDonald· 1 shared James I. McDonaldiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersCancer Biology

Pirunthan Perampalam

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

WNT8B and -9B promote the survival and dissemination of dormant ovarian cancer cells

Komila Zakirova, Daniel T. Passos, Chad Kelawan, Michael V. Roes, Rizwan Tahir, Malcolm Hill, Seung J. Kim, Matthew J. Cecchini, Marco Mura, Trevor G. Shepherd, Pirunthan Perampalam, James I. MacDonald, Frederick A. Dick

This study identifies WNT8B and WNT9B as critical for ovarian cancer cell survival and dissemination during dormancy, showing their inhibition could improve treatment outcomes.

bioRxiv · Aug 11, 2026 · PreprintCancer Biology

The DREAM complex links somatic mutation, lifespan, and disease

Zane Koch, Shuvro Prokash Nandi, Kate Licon, Arturo Bujarrabal-Dueso, David H. Meyer, Safa Saeed, Pirunthan Perampalam, Frederick A. Dick, Björn Schumacher, Ludmil B. Alexandrov, Trey E. Ideker

This study shows that DREAM complex activity influences somatic mutation burden, lifespan, and age-related disease, with reduced activity linked to longer lifespan and lower disease risk.

bioRxiv · Sep 15, 2025 · PreprintBioinformatics

GO-CRISPR: a highly controlled workflow to discover gene essentiality in loss-of-function screens

Pirunthan Perampalam, James I. McDonald, Frederick A. Dick

GO-CRISPR improves loss-of-function CRISPR screens by integrating guide-only controls and TRACS software, identifying novel pathways in tumor dormancy.

PLoS ONE · Dec 18, 2024Peer-reviewedSystems Biology