Beyond Metabolism: Pyruvate Carboxylase Acts as a Sequence-Selective Small RNA Sensor Orchestrating Antiviral Responses
Udeshika Kariyawasam, Suranjana Goswami, Ming Hao, Rosana Wiscovitch-Russo, Q Chen, Jun Yang, Ju Qu, Mayra Marquez, Hongyan Sui, Weizhong Chang, Tomozumi Imamichi
The paper shows miRTC14 activates IFN expression through interaction with pyruvate carboxylase and LGP2, leading to TBK1 phosphorylation and IFN subtype production.
bioRxiv · Aug 5, 2026 · PreprintImmunology