Cooperative progression of colitis and leukemia modulated by clonal hematopoiesis via PTX3/IL-1β; pro-inflammatory signaling
H. He, Y. Wen, H. Yu, J. Liu, Q. Huo, W. Jin, Z. Wang, G. Du, J. Du, H. Wang, Z. Zhao, Z. Cai
This study shows that clonal hematopoiesis driven by TET2 mutations interacts with inflammatory signals like PTX3/IL-1β to promote colitis and leukemia through a gut-bone marrow axis.
bioRxiv · Aug 29, 2023Immunology