H. Yokota

Different Physical Parameters in the Bonds between Platelet Glycoprotein Ibalpha with von Willebrand factor and with Coagulant Factor XI -Results from the Molecular Dynamic Simulation-

This study uses molecular dynamics simulations to compare the physical stability and binding energy of VWF-GPIb and FXI-GPIb bonds, finding VWF-GPIb more stable with higher binding energy.

Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins

The paper identifies osteosarcoma-enriched transcripts that encode extracellular tumor-suppressing proteins, suggesting a paradoxical therapeutic strategy using OS transcriptomes.

Receptor-linked environment-sensitive probe monitors the local membrane environment surrounding the insulin receptor

This paper develops a method to monitor the local membrane environment around the insulin receptor in living cells and finds it is dynamic, heterogeneous, and changes with receptor activation.

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

Evaluation of origin of driving force for loop formation in a chromatin fiber

The paper evaluates the energy sources driving chromatin loop formation using a lattice model, finding excluded volume interactions are essential regardless of thermal or ATP-driven energy.

Evaluation of origin of driving force for loop formation in a chromatin fiber

The paper was withdrawn due to a technical error causing duplicate posting, and the correct preprint is available at the provided DOI.