Tff2 marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injury
Ruhong Tu, Hua-Long Zheng, Biyun Zheng, Qing Zhong, Jin Qian, Qian Yu, Feijing Wu, Toshiro Shiokawa, Yosuke Ochiai, Hiroki Kobayashi, Quin T. Waterbury, Leah B. Zamechek, Youxin Gao, Satoru Takahashi, Seiya Mizuno, , Timothy Cragin Wang
This study identifies Tff2+ progenitors in the gastric corpus as the primary source of SPEM and gastric cancer following injury, showing they can bypass metaplasia and progress directly to dysplasia.
Gut · Apr 14, 2026Peer-reviewedCell Biology