Steven O. Smith

The paper investigates how mutations in the thrombopoietin receptor (TpoR) affect its activation and oncogenicity by altering the helical structure at the cytosolic boundary of the transmembrane domain.

The paper identifies an electrostatic cluster in A{beta}40 fibrils from CAA patients that influences fibril formation and differs from AD fibrils.

The paper shows that dimeric orientations of C99 influence γ-secretase cleavage lines, affecting Aβ42 processing and gene transcription.