Author

R. N. Germain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 6 Cancer Biology· 1 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 5 Organism:mouse· 5 Research Focus:cell type annotation· 4 Assay:imaging· 4 Research Focus:differential expression· 3 Assay:spatial transcriptomics· 3 Approach:deep learning· 2

Frequent Co-Authors

A. J. Radtke· 3 shared A. C. Indart· 2 shared A. Marson· 2 shared A. Young· 2 shared D. R. Simeonov· 2 shared E. Speranza· 2 shared H. S. Wong· 2 shared J. M. Hernandez· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

A. J. Radtke

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

A spatial human thymus cell atlas mapped to a continuous tissue axis

N. Yayon, V. R. Kedlian, L. Boehme, C. Suo, B. Wachter, R. T. Beuschel, O. Amsalem, K. Polanski, S. Koplev, E. Tuck, E. Dann, J. Van Hulle, S. Perera, T. Putteman, A. V. Predeus, , Tag

The paper maps the spatial organization of the human thymus across developmental stages using a multimodal atlas and identifies key cellular and molecular features of T cell development.

bioRxiv · Oct 25, 2023Immunology

Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk

D. R. Simeonov, K. Park, J. T. Cortez, A. Young, Z. Li, V. Nguyen, J. Umhoefer, A. C. Indart, J. Woo, M. S. Anderson, J. S. Tsang, R. N. Germain, H. S. Wong, A. Marson

The paper shows how non-coding variants affecting IL2RA enhancers alter T cell feedback circuits, leading to opposing autoimmune outcomes in mice.

bioRxiv · Jun 17, 2023 · PreprintImmunology

Agonistic anti-CD40 converts Tregs into Type 1 effectors within the tumor micro-environment

V. Maltez, C. Arora, R. Sor, Q. Lian, R. H. Vonderheide, R. N. Germain, K. T. Byrne

This study shows that agonistic anti-CD40 converts Tregs into Type 1 effectors in the tumor microenvironment via IL-12 and IFN-γ signaling from dendritic cells.

bioRxiv · Oct 17, 2022 · PreprintImmunology

A Multi-scale, Multiomic Atlas of Human Normal and Follicular Lymphoma Lymph Nodes

A. J. Radtke, E. Postovalova, A. Varlamova, A. Bagaev, M. Sorokina, O. Kudryashova, M. Meerson, M. Polyakova, I. Galkin, V. Svekolkin, S. Isaev, G. Perelman, Y. Lozinsky, Z. Yaniv, B. C. Lowekamp, , R. N. Germain

This study creates a multi-scale, multiomic atlas of human normal and follicular lymphoma lymph nodes to identify tumor-specific features and microenvironmental patterns associated with early relapse.

bioRxiv · Jun 3, 2022Cancer Biology

DNA origami patterning of synthetic T cell receptors reveals spatial control of the sensitivity and kinetics of signal activation

R. Dong, T. Aksel, W. Chan, R. N. Germain, R. D. Vale, S. M. Douglas

The paper uses DNA origami to pattern synthetic T cell receptors and shows how spatial arrangement affects signaling sensitivity and kinetics.

bioRxiv · Mar 12, 2021Cell Biology

IBEX: A versatile multi-plex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues

A. J. Radtke, E. Kandov, B. Lowekamp, E. Speranza, C. J. Chu, A. Gola, N. Thakur, R. Shih, L. Yao, Z. R. Yaniv, R. T. Beuschel, J. Kabat, J. Croteau, J. Davis, J. M. Hernandez, R. N. Germain

IBEX enables high-resolution, multi-plex imaging of over 65 parameters in tissue sections without degradation, supporting spatial analysis and integration with other technologies.

bioRxiv · Nov 20, 2020Immunology

Blood gene expression-based prediction of lethality after respiratory infection by influenza A virus in mice

P. Milanez-Almeida, A. J. Martins, P. Torabi-Parizi, L. M. Franco, J. S. Tsang, R. N. Germain

The paper develops a machine learning model using blood gene expression data to predict lethality in mice infected with influenza A virus.

bioRxiv · Oct 27, 2020 · PreprintImmunology

T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk

D. R. Simeonov, H. S. Wong, J. T. Cortez, A. Young, Z. Li, V. Nguyen, K. Park, J. Umhoefer, A. C. Indart, J. M. Woo, M. S. Anderson, R. N. Germain, A. Marson

This study identifies two enhancers regulating IL2RA expression in T cells, showing how their cell-type-specific effects influence autoimmune diabetes risk.

bioRxiv · Jul 22, 2020 · PreprintImmunology

Efficient immune cell genome engineering with improved CRISPR editing tools

Waipan Chan, R. A. Gottschalk, Y. Yao, J. Pomerantz, R. N. Germain

Doxycycline-inducible dual-color Cas9, purified lentivirus, puromycin-selected nickase HDR, integrase-deficient lentiviral HDR delivery and an all-in-one CRISPRa vector enable editing of macrophage and Jurkat T cells.

bioRxiv · Feb 13, 2020 · PreprintGenomics✦ In-depth digest