B. R. tenOever

Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity

This paper introduces self-assembling short duplex RNAs that induce interferon production and inhibit multiple respiratory viruses.

SARS-CoV-2 hijacks p38β/MAPK11 to promote viral protein translation

This study identifies p38β as a critical host factor for SARS-CoV-2 replication and shows that inhibiting it reduces viral replication and cytokine production.

SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta

This study investigates SARS-CoV-2 infection in placentas from infected pregnant women, finding that the virus infects syncytiotrophoblast cells and triggers maternal immune cell infiltration.

The host factor ANP32A is required for influenza A virus vRNA and cRNA synthesis

This study demonstrates that ANP32A is essential for both vRNA and cRNA synthesis in influenza A virus replication, challenging previous assumptions about its role.

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2

This study identifies BRD2 as a regulator of ACE2 transcription and shows that BRD2 inhibitors block SARS-CoV-2 infection in human cells and animal models.

Modulating the transcriptional landscape of SARS-CoV-2 as an effective method for developing antiviral compounds

This study identifies antiviral compounds that reduce SARS-CoV-2 viral load by counteracting the virus-induced transcriptional landscape, without affecting viral entry or host antiviral response.

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

Identification of Drugs Blocking SARS-CoV-2 Infection using Human Pluripotent Stem Cell-derived Colonic Organoids

This study uses human pluripotent stem cell-derived colonic organoids to identify drugs that block SARS-CoV-2 infection, finding mycophenolic acid and quinacrine dihydrochloride effective in vitro and in vivo.

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

This paper demonstrates the use of human organ chips to rapidly repurpose therapeutics for viral pandemics, identifying amodiaquine as a potential treatment for SARS-CoV-2.

SARS-CoV-2 launches a unique transcriptional signature from in vitro, ex vivo, and in vivo systems

This study characterizes the host transcriptional response to SARS-CoV-2 and other respiratory viruses in multiple models, finding a unique muted response lacking certain cytokine and chemokine induction.

Rapid dissemination and monopolization of viral populations in mice revealed using a panel of barcoded viruses

This study tracks viral population dynamics in orally infected mice using barcoded coxsackieviruses, revealing rapid dissemination followed by diversity restriction and monopolization in tissues.