Author

J. Steel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. C. Lowen· 3 shared N. T. Jacobs· 2 shared A. Antia· 1 shared A. Chronopoulos· 1 shared A. Cox· 1 shared A. del Rio Hernandez· 1 shared A. Farrugia· 1 shared A. Garcia-Sastre· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersMicrobiology

A. C. Lowen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A single amino acid substitution in PB1 of pandemic H1N1 with A/Ann Arbor/6/60 master donor virus mutations as a novel live-attenuated influenza virus vaccine

A. Nogales, J. Steel, W.-C. Liu, A. C. Lowen, L. Rodriguez, K. Chiem, A. Cox, A. Garcia-Sastre, R. Albrecht, S. Dewhurst, L. Martinez-Sobrido

This paper shows that a single amino acid change in the PB1 protein of the pandemic H1N1 virus can create a live-attenuated vaccine with reduced pathogenicity and transmission.

bioRxiv · Jan 7, 2022 · PreprintMicrobiology

Dysregulation of M segment gene expression contributes to influenza A virus host restriction

B. M. Calderon, S. Danzy, G. K. Delima, N. T. Jacobs, K. Ganti, M. R. Hockman, G. L. Conn, A. C. Lowen, J. Steel

This study identifies dysregulation of M segment gene expression, particularly M2 overexpression, as a key factor in avian influenza A virus restriction in mammalian hosts.

PLOS Pathogens · Aug 15, 2019Peer-reviewedMicrobiology

Incomplete influenza A virus genomes are abundant but readily complemented during spatially structured viral spread

N. T. Jacobs, N. O. Onuoha, A. Antia, R. Antia, J. Steel, A. C. Lowen

The paper quantifies incomplete influenza A virus genomes (IVGs) and shows they require complementation for replication, but spatial structure facilitates this process, supporting viral spread but not transmission.

bioRxiv · Jan 23, 2019Microbiology

SREBP1 drives KRT80-dependent cytoskeletal changes and invasive behavior in endocrine resistant ERα breast cancer

L. Magnani, Y. Perone, A. Farrugia, A. Meira, B. Gyorffy, C. Ion, A. Uggetti, D. Patten, A. Chronopoulos, M. Faronato, S. Shousha, J. Steel, C. Davies, N. Patel, A. del Rio Hernandez, , F. Calvo

This study identifies SREBP1-driven KRT80 upregulation as a mechanism promoting invasion in endocrine-resistant ERα breast cancer through cytoskeletal changes and increased tumor stiffness.

bioRxiv · Jul 30, 2018Cancer Biology