J. Hiatt

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

This study evaluates the efficacy of host-directed therapies against the B.1.1.7 SARS-CoV-2 variant and finds similar antiviral activity compared to early-lineage SARS-CoV-2.

TCF-1 regulates the stem-like memory potential of HIV-specific CD8+ T cells in elite controllers

The paper shows TCF-1 enhances HIV-specific CD8+ T cell expansion and memory properties in elite controllers.

Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5alpha Binding to the viral Core

Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits

This paper develops a platform to discover synthetic DNA sequences that enhance T cell functions by integrating them into endogenous genomic sites.

Light-Activated Cell Identification and Sorting (LACIS): A New Method to Identify and Select Edited Clones on a Microfluidic Device

The paper introduces LACIS, a microfluidic method for identifying and sorting edited clones using Opto-Electronic Positioning, enabling rapid and efficient clonal selection after CRISPR-Cas9 editing.