Author

J. Eyquem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:CRISPR screen· 3 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. J. Ye· 2 shared P. Ho· 2 shared R. Bueno· 2 shared A. M. R. Marson· 1 shared A. Marson· 1 shared A. Satpathy· 1 shared A. To· 1 shared B. Hwang· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

C. J. Ye

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Spatiotemporal Control of Genomics and Epigenomics by Ultrasound

Y. Wu, Z. Huang, Y. Liu, C.-W. Yoon, K. Sun, Y. Situ, P. Ho, Z. Yuan, L. Zhu, J. Eyquem, Y. Zhao, T. Liu, G. A. Kwong, S. Chien, Y. Wang

This paper develops FUS-CRISPR(a/i) tools to remotely control gene expression and epigenetic modifications in vivo, showing therapeutic effects in tumor models.

bioRxiv · Jun 21, 2023 · PreprintBioengineering

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

C. A. Tsuchida, N. Brandes, R. Bueno, M. Trinidad, T. Mazumder, B. Yu, B. Hwang, C. Chang, J. Liu, Y. Sun, C. R. Hopkins, K. R. Parker, Y. Qi, A. Satpathy, E. Stadtmauer, , J. A. Doudna

This study investigates chromosome loss in CRISPR-Cas9-engineered T cells and shows a modified manufacturing process reduces it while preserving editing efficacy.

bioRxiv · Mar 22, 2023Cell Biology

Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies

F. Blaeschke, Y. Y. Chen, R. Apathy, Z. Li, C. T. Mowery, W. A. Nyberg, A. To, R. Yu, R. Bueno, M. C. Kim, R. Schmidt, D. B. Goodman, T. Feuchtinger, J. Eyquem, C. J. Ye, , A. Marson

The paper develops ModPoKI, a platform for modular construction of DNA knockin libraries to identify gene constructs that enhance T cell function and persistence.

bioRxiv · Jul 27, 2022Immunology

The CD28-transmembrane domain mediates chimeric antigen receptor heterodimerization with CD28

Y. Muller, D. Nguyen, L. M. R. Ferreira, P. Ho, C. Raffin, R. Beltran Valencia, Z. Congrave-Wilson, T. Roth, J. Eyquem, F. Van Gool, A. M. R. Marson, J. A. Wells, J. A. Bluestone, Q. Tang

This paper shows that CD28-TMD in CARs forms heterodimers with endogenous CD28, affecting T-cell responses and surface expression.

bioRxiv · Sep 18, 2020Bioengineering