Rapid discovery of synthetic DNA sequences to rewrite endogenous T cell circuits
T. L. Roth, P. J. Li, J. Nies, R. Yu, M. L. T. Nguyen, Y. Lee, R. Apathy, A. Truong, J. Hiatt, D. Wu, D. N. Nguyen, D. Goodman, J. A. Bluestone, K. Roybal, E. Shifrut, A. Marson
This paper develops a platform to discover synthetic DNA sequences that enhance T cell functions by integrating them into endogenous genomic sites.
bioRxiv · Apr 12, 2019 · PreprintImmunology