R. B. Stockbridge

Peripheral mutations underlie promiscuous transport of quaternary ammonium antiseptics by Small Multidrug Resistance transporters

The paper identifies peripheral mutations that enable promiscuous transport of quaternary ammonium antiseptics by SMR transporters, revealing that substrate preference changes through mutations outside the binding pocket.

Transport of metformin metabolites by guanidinium exporters of the Small Multidrug Resistance family

This study examines how bacterial SMR transporters handle metformin metabolites, showing they efficiently export guanylurea and providing insights into their function and potential role in microbial adaptation.

Fluoride export is required for competitive fitness of pathogenic microorganisms in dental biofilm models

This study shows that genetic knockout of fluoride export proteins in pathogenic oral microbes reduces their fitness in biofilms, altering microbial composition and pathogenic properties.

Lysosome transporter purification and reconstitution identifies Ypq1 as a pH-gated lysine transporter

The paper develops a method to overexpress, purify, and reconstitute the lysine transporter Ypq1 in yeast vacuoles, demonstrating its pH-gated transport function and lysine-dependent stability.

Dimerization mechanism of an inverted-topology ion channel in membranes

This study investigates the dimerization mechanism of the inverted-topology fluoride channel Fluc, showing that membrane forces drive assembly while Na+ binding activates the channel.

Crystal structures of bacterial Small Multidrug Resistance transporter EmrE in complex with structurally diverse substrates

The paper determines crystal structures of EmrE, a bacterial SMR transporter, in complex with various substrates, revealing structural flexibility in the binding site.

The fluoride permeation pathway and anion recognition in Fluc family fluoride channels

This study identifies fluoride binding sites and anion recognition mechanisms in Fluc family channels using structural and electrophysiological methods.