J. D. Faraldo-Gomez

This study uses enhanced molecular dynamics simulations to quantify cholesterol-induced stiffening in lipid membranes and shows its lipid-specific nature.

This study investigates the dimerization mechanism of the inverted-topology fluoride channel Fluc, showing that membrane forces drive assembly while Na+ binding activates the channel.

This paper uses simulations to map the free-energy landscapes of a Na+/Ca2+ exchanger, explaining its antiporter function, specificity, and 3:1 stoichiometry.

This paper investigates how lipid bilayer deformations influence the gating of MscS ion channels, showing that tension shifts the equilibrium by increasing the energy cost of closed-state membrane protrusions.

The paper investigates the ion selectivity mechanism of TMEM175, showing that its unique hydrophobic constriction and electrostatic field enable K+ selectivity without a canonical filter.

This paper introduces HDXer, a method to generate structural ensembles from HDX-MS data using maximum-entropy reweighting, demonstrating its ability to recover accurate structural information from simulated data.

This study shows mitochondrial ATP synthase dimers spontaneously form rows in cristae due to membrane-induced forces, not protein interactions or lipid composition.