Author

S. Strack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Assay:proteomics· 3 Approach:biophysical modeling· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

C.-G. Wu· 2 shared R. A. Merrill· 2 shared V. K. Balakrishnan· 2 shared Y. Xing· 2 shared A. Musiyenko· 1 shared A. P. Bravos· 1 shared A. Suzuki· 1 shared A. Y. Usachev· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersBiochemistry

C.-G. Wu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular Determinants and Signaling Effects of PKA RIα Phase Separation

J. C. Hardy, E. H. Pool, J. G. H. Bruystens, X. Zhou, Q. Li, D. R. Zhou, M. Palay, G. Tan, L. Chen, J. L. C. Choi, H. N. Lee, S. Strack, D. Wang, S. S. Taylor, S. Mehta, J. Zhang

This study identifies molecular determinants of PKA RIα phase separation and shows how it regulates cAMP compartmentation and PKA-C spatial restriction.

bioRxiv · Dec 10, 2023Cell Biology

Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

C.-G. Wu, V. K. Balakrishnan, P. S. Parihar, K. Konovolov, Y.-C. Chen, R. A. Merrill, H. Wei, B. Carragher, R. Sundaresan, Q. Cui, B. E. Wadzinski, M. R. Swingle, A. Musiyenko, R. Honkanen, W. K. Chung, , Y. Xing

The paper investigates the structural and functional dynamics of the PP2A-B56δ holoenzyme, showing how mutations linked to intellectual disability affect its allosteric network and phosphorylation rates.

bioRxiv · Mar 9, 2023 · PreprintBiochemistry

Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition

Y. Li, V. K. Balakrishnan, M. Rowse, C.-G. Wu, A. P. Bravos, V. K. Yadav, Y. Ivarsson, S. Strack, I. V. Novikova, Y. Xing

This study shows PME-1 demethylates PP2A holoenzymes and inhibits substrate recognition through structural interactions with the B56 subunit, revealing mechanisms of PME-1 activity and its role in p53 signaling.

bioRxiv · Jul 1, 2022Biochemistry

The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis

J. Song, R. A. Merrill, A. Y. Usachev, S. Strack

This study identifies KLHL15 as an E3 ubiquitin ligase that degrades doublecortin proteins, regulating dendritic development in neurons.

bioRxiv · Oct 2, 2020Biochemistry

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum

W.-K. Ji, R. Chakrabarti, X. Fan, L. Schoenfeld, S. Strack, H. N. Higgs

This paper identifies ER-associated Drp1 oligomers formed via Mff and shows their role in mitochondrial division.

bioRxiv · Sep 18, 2017Cell Biology