Author

R. Friemann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:structural biology· 2 Assay:cryo-EM· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

C. Indiveri· 2 shared M. Currie· 2 shared M. Scalise· 2 shared R. Dobson· 2 shared R. Subramanian· 2 shared A. Gulati· 1 shared A. Wollman· 1 shared B. Demeler· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiochemistry

C. Indiveri

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

On the function of TRAP substrate-binding proteins: conformational variation of the sialic acid binding protein SiaP

T.-R. J. King-Hudson, J. S. Davies, S. Quan, M. Currie, Z. D. Tillett, J. Copping, S. Panjikar, R. Friemann, J. R. Allison, R. A. North, R. Dobson

This study solves the structure of the TRAP substrate-binding protein AaSiaP in different conformations, revealing how it binds N-acetylneuraminate and stabilizes a closed state.

bioRxiv · Apr 30, 2024Biochemistry

Molecular determinants of Neu5Ac binding to tripartite ATP independent periplasmic (TRAP) transporter

P. Goyal, K. Dhanabalan, M. Scalise, R. Friemann, C. Indiveri, R. C. Dobson, K. R. Vinothkumar, R. Subramanian

The paper reports the structures of SiaQM from Fusobacterium nucleatum with and without Neu5Ac, revealing interactions and transport mechanisms.

bioRxiv · Mar 29, 2024Biochemistry

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

M. Currie, J. Davies, M. Scalise, A. Gulati, J. Wright, M. Newton-Vesty, G. Abeysekera, R. Subramanian, W. Wahlgren, R. Friemann, J. Allison, P. Mace, M. Griffin, B. Demeler, S. Wakatsuki, , R. North

This study reports the cryo-EM structure of a TRAP transporter from Haemophilus influenzae, revealing its dimeric architecture, Na+ sites, and substrate binding site, supported by mutagenic and functional data.

bioRxiv · Aug 28, 2023 · PreprintBiochemistry

Transcription factor clusters regulate genes in eukaryotic cells

A. Wollman, S. Shashkova, E. Hedlund, R. Friemann, S. Hohmann, M. C. Leake

The paper shows transcription factors form clusters that regulate gene expression in yeast by reducing search times and stabilizing expression.

bioRxiv · Apr 6, 2017Biophysics