Author

M. P. Cosma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:ChIP-seq· 2 Organism:mouse· 2

Frequent Co-Authors

E. Pedone· 2 shared M. Lakadamyali· 2 shared M. V. Neguembor· 2 shared A. Bhamra· 1 shared A. Castells Garcia· 1 shared A. Castells-Garcia· 1 shared A. Hutchins· 1 shared A. Kant· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCell Biology

E. Pedone

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

coRIC map: a framework for the exploration of multifaceted subcellular RNA-binding proteins

M. A. Esteban, Y. lv, X. Guo, J. Hu, S. Kanwal, J. Yuan, M. Tariq, J. Zheng, M. Sun, Y. Lu, J. Wang, M. Jiang, A. Wang, A. Castells-Garcia, X. Zheng, , X. Zhang

The paper introduces coRIC map, an experimental and analytical framework to study subcellular RNA-binding protein dynamics and interactions, revealing new functions and stress responses.

bioRxiv · Nov 6, 2023 · PreprintCell Biology

Active Transcription and Epigenetic Reactions Synergistically RegulateMeso-Scale Genomic Organization

A. Kant, Z. Guo, V. Vinayak, M. V. Neguembor, W. S. Li, V. Agrawal, E. Pujadas, L. M. Almassalha, V. Backman, M. Lakadamyali, M. P. Cosma, V. Shenoy

This study introduces a mesoscale model to show how transcription and epigenetic reactions regulate heterochromatin domain sizes, finding that transcription loss increases domain size and compaction.

bioRxiv · Apr 21, 2023Biophysics

Cohesin-independent STAG proteins interact with RNA and localise to R-loops to promote complex loading.

H. Porter, Y. Li, W. Varsally, M. V. Neguembor, M. Beltran, D. Pezic, L. Martin, M. Tavares Cornejo, A. Bhamra, S. Surinova, R. G. Jenner, M. P. Cosma, S. HADJUR

The paper shows SA proteins interact with RNA and R-loops to promote cohesin loading independently of NIPBL, revealing a new role in chromatin structure and cancer biology.

bioRxiv · Feb 20, 2021Cell Biology

Senolytic treatment targets aberrant p21-expression to restore liver regeneration in adult mice

B. Ritschka, T. Knauer-Meyer, A. Mas, J.-L. Plassat, D. Sampaio Goncalves, H. Jacobs, E. Pedone, U. Di Vicino, M. P. Cosma, W. M. Keyes

This study shows that senolytic drugs improve liver regeneration in adult mice by targeting aberrant p21 expression, while p16Ink4a expression remains unaffected.

bioRxiv · Sep 5, 2019Cell Biology

Canonical Wnt pathway controls mESCs self-renewal through inhibition of spontaneous differentiation via β-catenin/TCF/LEF functions

F. Aulicino, F. Sottile, E. Pedone, F. Lluis, L. Marucci, M. P. Cosma

This study shows that canonical Wnt signaling inhibits mESC differentiation by β-catenin/TCF/LEF functions, and that non-functional β-catenin isoforms can rescue self-renewal defects.

bioRxiv · Jun 16, 2019Cell Biology

Nanoscale decompaction of nucleosomal DNA revealed through multi-color super-resolution microscopy

J. Otterstrom, A. Castells Garcia, C. Vicario, M. P. Cosma, M. Lakadamyali

The paper uses super-resolution microscopy to show that DNA is compacted by nucleosome groups (clutches) and that hyperacetylation reduces clutch DNA compaction, especially in regions with multiple nearby clutches.

bioRxiv · Nov 14, 2018 · PreprintCell Biology