Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus
I. R. Monk, N. Shaikh, S. L. Begg, M. Gajdiss, J. Y. H. Lee, S. J. Pidot, T. Seemann, M. Kuiper, B. Winnen, R. Hvorup, B. M. Collins, G. Bierbaum, B. P. Howden, C. A. McDevitt, G. F. King, T. P. Stinear
The paper identifies zinc binding to the WalK histidine kinase's PAS domain as a negative regulator of the WalKR two-component system in Staphylococcus aureus.
bioRxiv · Aug 31, 2018Microbiology