Author

I. R. Monk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Assay:DNA methylation· 2 Organism:human· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

S. J. Pidot· 6 shared T. P. Stinear· 6 shared B. P. Howden· 5 shared T. Seemann· 4 shared G. P. Carter· 3 shared J. Y. H. Lee· 3 shared R. Guerillot· 3 shared A. Goncalves da Silva· 2 shared

Activity by Year

2016-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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6 shared papersMicrobiology

S. J. Pidot

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Author profile →

6 papers

Recent·Most cited

A marine sponge-associated mycobacterium closely related to Mycobacterium tuberculosis

S. J. Pidot, S. Klatt, L. S. Ates, W. Frigui, F. Sayes, L. Majlessi, H. Izumi, I. R. Monk, J. L. Porter, V. Bennett-Wood, T. Seemann, A. Otter, G. Taiaroa, G. M. Cook, N. West, , T. P. Stinear

This paper describes the discovery of a marine sponge-associated mycobacterium closely related to M. tuberculosis, which shares virulence factors but lacks virulence in mice.

bioRxiv · Jan 23, 2024 · PreprintMicrobiology

The two-component regulator WalKR provides an essential link between cell wall homeostasis with DNA replication in Staphylococcus aureus

L. K. R. Sharkey, R. Guerillot, C. J. Walsh, A. M. Turner, J. Y. H. Lee, S. L. Neville, S. Klatt, S. L. Baines, S. J. Pidot, F. J. Rossello, T. Seeman, H. McWilliam, E. Cho, G. P. Carter, B. P. Howden, , I. R. Monk

This study identifies the WalKR two-component system in Staphylococcus aureus as a polyfunctional regulator linking cell wall homeostasis with DNA replication and other essential processes.

bioRxiv · Feb 27, 2023 · PreprintMicrobiology

Validation of a Single-step, Single-tube Reverse Transcription-Loop-Mediated Isothermal Amplification Assay for Rapid Detection of SARS-CoV-2 RNA

J. Y. Lee, N. Best, J. L. McAuley, J. Porter, T. Seemann, M. B. Schultz, M. Sait, N. Orlando, K. Mercoulia, S. A. Ballard, J. Druce, T. Tran, M. Catton, M. J. Pryor, H. L. Cui, , T. P. Stinear

The paper validates a single-step, single-tube RT-LAMP assay for rapid SARS-CoV-2 detection with high specificity and sensitivity.

Journal of Medical Microbiology · Sep 1, 2020Peer-reviewedMicrobiology

Functional genomics reveals extensive diversity in Staphylococcus epidermidis restriction modification systems compared to Staphylococcus aureus.

J. Y. Lee, G. P. Carter, S. J. Pidot, R. Guerillot, T. Seeman, A. Goncalves da Silva, T. J. Foster, B. P. Howden, T. P. Stinear, I. R. Monk

The paper identifies extensive diversity in type I restriction modification systems in Staphylococcus epidermidis compared to Staphylococcus aureus, enabling efficient genetic manipulation of clinically relevant strains.

bioRxiv · May 22, 2019 · PreprintMicrobiology

Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus

I. R. Monk, N. Shaikh, S. L. Begg, M. Gajdiss, J. Y. H. Lee, S. J. Pidot, T. Seemann, M. Kuiper, B. Winnen, R. Hvorup, B. M. Collins, G. Bierbaum, B. P. Howden, C. A. McDevitt, G. F. King, T. P. Stinear

The paper identifies zinc binding to the WalK histidine kinase's PAS domain as a negative regulator of the WalKR two-component system in Staphylococcus aureus.

bioRxiv · Aug 31, 2018Microbiology

Increasing tolerance of hospital Enterococcus faecium to hand-wash alcohols

S. J. Pidot, W. Gao, A. H. Buultjens, I. R. Monk, R. Guerillot, G. P. Carter, J. Y. H. Lee, M. M. C. Lam, S. A. Ballard, M. L. Grayson, A. A. Mahony, E. A. Grabsch, D. Kotsanas, T. Korman, G. W. Coombs, , T. P. Stinear

The paper shows hospital Enterococcus faecium isolates from 2010 onward are 10-fold more tolerant to alcohol-based disinfectants than older isolates, leading to increased gastrointestinal colonization in mice.

bioRxiv · May 16, 2016Microbiology