Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
N. Modhiran, S. M. Lauer, A. A. Amarilla, P. Hewins, S. I. L. van den Broek, Y. S. Low, N. Thakur, B. Liang, G. V. Nieto, J. Jung, D. Paramitha, A. Isaacs, J. de Sng, D. Song, J. Jorgensen, , D. Watterson
This paper identifies a nanobody that effectively neutralizes the SARS-CoV-2 Omicron variants BA.1 and BA.2, showing high affinity and pre-clinical promise.
bioRxiv · Dec 27, 2022 · PreprintMicrobiology
R. Stewart, K. Yan, S. A. Ellis, C. R. Bishop, T. Dumenil, B. Tang, W. Nguyen, T. Larcher, R. Parry, J. D. J. Sng, A. A. Khromykh, R. K. P. Sullivan, M. Lor, F. A. Meunier, D. J. Rawle, A. Suhrbier
This study shows that omicron BA.5 and XBB variants are more neurovirulent than BA.1 in mice and human brain organoids, leading to increased brain infection and mortality.
bioRxiv · Dec 22, 2022 · PreprintMicrobiology
M. W. Lo, A. A. Amarilla, J. D. Lee, E. A. Albornoz, N. Modhiran, R. J. Clark, V. Ferro, M. Chhabra, A. A. Khromykh, D. Watterson, T. M. Woodruff
This study shows SARS-CoV-2 activates the complement system via heparan sulfate interactions, leading to C5a production and delayed granulocyte/monocyte activation.
bioRxiv · Jan 11, 2022Immunology
A. Slonchak, R. Parry, B. Pullinger, J. D. J. Sng, X. Wang, T. F. Buck, F. J. Torres, J. J. Harrison, A. M. G. Colmant, J. Hobson-Peters, R. A. Hall, A. Tuplin, A. A. Khromykh
This study analyzes 3'UTRs of insect flaviviruses to identify novel xrRNAs involved in sfRNA biogenesis and provides insights into flavivirus evolution.
bioRxiv · Jun 23, 2021Microbiology
C. L. D. McMillan, J. J. Y. Choo, A. Idris, A. Supramaniam, N. Modhiran, A. A. Amarilla, A. Isaacs, S. T. M. Cheung, B. Liang, H. Bielefeldt-Ohmann, A. Azuar, D. Acharya, G. Kelly, G. J. P. Fernando, M. J. Landsberg, , D. A. Muller
A single dose of a SARS-CoV-2 spike vaccine delivered via a high-density microarray patch provides complete protection against a lethal virus challenge.
bioRxiv · May 30, 2021Microbiology
A. Slonchak, X. Wang, H. Chaggar, J. Aguado, M. Freney, K. Yan, F. J. Torres, A. A. Amarilla, R. Balea, J. D. J. Sng, Y. X. Setoh, N. Peng, D. Watterson, E. Wolvetang, A. Suhrbier, A. A. Khromykh
This study identifies how ZIKV sfRNA interacts with NS5 to inhibit STAT1 phosphorylation, promoting viral pathogenesis in placental and neural tissues.
bioRxiv · May 18, 2021Microbiology
Y. Zhu, K. Y. Chew, M. Wu, A. C. Karawita, G. McCallum, L. E. Steele, A. Yamamoto, L. L. Labzin, T. Yarlagadda, A. A. Khromykh, X. Wang, J. Sng, C. J. Stocks, Y. Xia, T. R. Kollmann, , K. R. Short
The paper compares SARS-CoV-2 replication in pediatric and adult nasal epithelial cells, finding lower viral titers in children for ancestral and Delta variants, but higher replication for Omicron.
bioRxiv · Mar 8, 2021 · PreprintMicrobiology
S. E. Guimond, C. J. Mycroft-West, N. S. Gandhi, J. A. Tree, T. T. Le, C. M. Spalluto, M. V. Humbert, K. R. Buttigieg, N. Coombes, M. J. Elmore, K. Nystrom, J. Said, Y. X. Setoh, A. Amarilla, N. Modhiran, , J. E. Turnbull
This paper shows that pixatimod inhibits SARS-CoV-2 by disrupting the Spike-ACE2 interaction, demonstrating its potential as an anti-COVID-19 therapeutic.
bioRxiv · Jun 24, 2020Microbiology