A. Mitra

Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

The paper identifies disease-associated states in PASMC and PAAF from IPAH patients and identifies potential modulators of PASMC phenotypic transition.

Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other

This study shows that human kinesin-5 KIF11 drives helical motion and orbiting of microtubules, enabling flexible filament organization and torque regulation during mitosis.

IFT cargo and motors associate sequentially with IFT trains to enter cilia

The paper uses single-molecule imaging to show that IFT components associate sequentially with IFT trains in C. elegans cilia, revealing their transport dynamics and the role of kinesin-II in axonemal organization.

A small excitation window allows long-duration single-molecule imaging, with reduced background autofluorescence, in C. elegans neurons

This paper introduces SWIM, a method for long-duration single-molecule imaging in C. elegans neurons by using small excitation windows to reduce background autofluorescence and improve imaging quality.

Guiding Irregular Nuclear Morphology on Nanopillar Array for Malignancy Differentiation in Tumor cells

This paper uses nanopillar arrays to quantify subnuclear morphology in tumor cells, showing it correlates with malignancy and drug response.

The terminal heme synthetic enzyme, Coproheme Decarboxylase, coordinates heme synthesis and uptake in response to iron in Mycobacteria

This study identifies Coproheme Decarboxylase (ChdC) as a regulator of heme synthesis and uptake in Mycobacterium tuberculosis, showing it controls heme bioavailability and iron acquisition in response to iron availability.

Occurrences of protonated base triples in RNA are determined by their cooperative binding energies and specific functional requirements

The paper identifies over 55 types of protonated base triples in RNA, showing their structural roles and energetic contributions to RNA stability and dynamics.

Molecular analysis of prostate cancer: prostate tissue and urine proteomics based approach

This study uses proteomics to compare prostate cancer and BPH, finding reduced latent TGF-binding protein in both tissue and urine, suggesting it as a potential non-invasive biomarker.

Differential expression of proteins in human prostate cancer tissues probed by MALDI imaging mass spectrometry

The paper uses MALDI imaging mass spectrometry to identify differentially expressed proteins in human prostate cancer tissues and suggests potential diagnostic biomarkers.

Dynamic evolution of cervical cancer mutations during chemoradiation using novel sampling approach

This study uses whole exome sequencing to track cervical cancer mutations during chemoradiation, finding that CDK4/CDK6/cyclin D1-related mutations persist or increase, suggesting radiation resistance.

The kinesin-14, Ncd, drives a right-handed, helical motion of antiparallel microtubules around each other

This study investigates the motion of microtubules driven by the kinesin-14 Ncd, revealing right-handed helical motion in antiparallel configurations and static behavior in parallel ones.

Pairing interactions between nucleobases and ligands in aptamer:ligand complexes of riboswitches: Crystal structure analysis, classification, optimal structures and accurate interaction energies

The paper analyzes 67 riboswitch aptamer:ligand complexes to classify and quantify base:ligand hydrogen bonding interactions, revealing their structural and energetic properties.

A Brownian ratchet model explains the biased sidestepping movement of single-headed kinesin-3 KIF1A

The paper explains how single-headed KIF1A motors produce left-handed helical motion by sidestepping on microtubules, using experimental and simulation data.

Structural landscape of base pairs containing post-transcriptional modifications in RNA

The paper analyzes modified base pairs in RNA structures to understand their structural and functional roles through geometric and energetic analysis.