G. Brown

HyphAeon: Attention on Evolution Across Deep Time Transforms Comparative Genomics

HyphAeon is a transformer model that accelerates detection of episodic diversifying selection in mammalian genomes and enables new analytical capabilities beyond traditional dN/dS methods.

Single-cell measurement of microbial growth rate with Raman microspectroscopy

This paper evaluates Raman microspectroscopy as a method to measure microbial growth rates using deuterium incorporation, showing its reliability and comparison with nanoSIMS.

Global monitoring of soil animal communities using a common methodology

The paper introduces a global collaborative network to standardize soil animal community monitoring and food web analysis across diverse ecosystems.

Metabolite Damage and Damage-Control in a Minimal Genome

The paper identifies and validates genes involved in metabolite damage repair and preemption in the minimized Mycoplasma JCVI-Syn3A genome and extends its metabolic map.

Limited variation between SARS-CoV-2-infected individuals in domain specificity and relative potency of the antibody response against the spike glycoprotein

The paper analyzes antibody responses in SARS-CoV-2-infected individuals, finding limited variation in domain specificity and relative neutralization potency across subjects.

The terminal heme synthetic enzyme, Coproheme Decarboxylase, coordinates heme synthesis and uptake in response to iron in Mycobacteria

This study identifies Coproheme Decarboxylase (ChdC) as a regulator of heme synthesis and uptake in Mycobacterium tuberculosis, showing it controls heme bioavailability and iron acquisition in response to iron availability.

Memory-like B cells emerging from germinal centres recycle through the subcapsular sinus

The paper tracks B cells exiting germinal centers and shows they recycle through the subcapsular sinus, interacting with macrophages and returning to GCs via CCL21 gradients, supporting affinity maturation to antigenic drift.

High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria

Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics

This study uses live-cell 3D single-molecule tracking to show that the NuRD complex decompacts chromatin and alters enhancer dynamics by increasing their movement and reducing time in a fast-diffusing state.

Transinfection of buffalo flies (Haematobia exigua) with Wolbachia and effect on host biology

This study injects Wolbachia strains into buffalo flies to assess their impact on host biology, finding strain-specific effects on survival, reproduction, and fecundity.

Modulation of T helper 1 and T helper 2 immune balance in a stress mouse model during Chlamydia muridarum genital infection

This study shows cold-induced stress modulates Th1/Th2 balance in mice infected with Chlamydia muridarum by increasing Th2 cytokines and decreasing Th1 cytokines.

Wolbachia successfully replicate in a newly established horn fly, Haematobia irritans irritans (L.) (Diptera: Muscidae) cell line

The paper establishes a continuous horn fly cell line infected with Wolbachia strains and shows stable persistence of infection over multiple passages.

Global distribution of earthworm diversity

The paper predicts global patterns of earthworm diversity, abundance, and biomass using a dataset from 7000 sites, finding climate drives these patterns but with differences from aboveground taxa.

Flux balance analysis predicts NADP phosphatase and NADH kinase are critical to balancing redox during xylose fermentation in Scheffersomyces stipitis