An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants
H. Ishigaki, F. Yasui, M. Nakayama, A. Endo, N. Yamamoto, K. Yamaji, C. T. Nguyen, Y. Kitagawa, T. Sanada, T. Honda, T. Munakata, M. Higa, S. Toyama, R. Kono, A. Takagi, , M. Kohara
This study develops a vaccinia-based vaccine encoding SARS-CoV-2 spike protein that induces broad and durable immunity, protecting against multiple variants in non-human primates and transgenic mice.
bioRxiv · Jun 12, 2022 · PreprintMicrobiology