N. Yamamoto

In vivo Stability and Biodistribution of Liposome Coated with SlpB from Levilactobacillus brevis

This study demonstrates that SlpB-coated liposomes improve stability in the gastrointestinal tract and enhance specific uptake into Peyers patches, increasing drug bioavailability and reducing liver retention.

Identification of host-interacting domains of surface layer protein B from Levilactobacillus brevis and the evidence as glycoprotein

The paper identifies sugar-containing fragments in SlpB from Levilactobacillus brevis and confirms their role in DC-SIGN interaction through competitive assays and mass spectrometry.

Two unique biological response-modifier glucans beneficially regulating gut microbiota and faecal metabolome in a non-alcoholic steatohepatitis animal model, with potential for applications in human health and disease

This study evaluates the effects of two glucans on gut microbiota and metabolome in a NASH model, showing beneficial changes in microbial composition and metabolite levels.

An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants

This study develops a vaccinia-based vaccine encoding SARS-CoV-2 spike protein that induces broad and durable immunity, protecting against multiple variants in non-human primates and transgenic mice.

Structural development of amyloid precursors in insulin B chain and the inhibition effect by fibrinogen

This study investigates the structural development of insulin B chain prefibrillar intermediates and how fibrinogen inhibits their fibril formation using multiple biophysical techniques.

Fast in-vitro screening of FLT3-ITD inhibitors using silkworm-baculovirus protein expression system

The paper expresses and purifies FLT3-ITD protein using a silkworm-baculovirus system and identifies two potent inhibitors through an inhibition assay.

Multistep changes in amyloid structure that are induced by cross-seeding on a rugged energy landscape

This study investigates how cross-seeding of insulin amyloid fibrils from different species leads to structural changes and new amyloid forms with distinct properties.

Nelfinavir inhibits replication of severe acute respiratory syndrome coronavirus 2 in vitro.

This study shows nelfinavir, an HIV-1 protease inhibitor, potently inhibits SARS-CoV-2 replication in vitro with EC50 and EC90 values lower than lopinavir.

Iodine staining as a useful probe for distinguishing amyloid fibril polymorphs

The paper demonstrates that iodine staining can distinguish amyloid fibril polymorphs by color differences, linked to specific iodine binding sites and surface structures.

Silicon Nanowires for Intracellular Optical Interrogation with Sub-Cellular Resolution

This paper demonstrates the use of silicon nanowires for sub-cellular optical stimulation in cells, showing their viability, calcium flux induction, and electrical coupling capabilities.

Evaluation of the impact of seasonal variations in photoperiod on the hepatic metabolism of medaka (Oryzias latipes)

This study examines how short-day photoperiod affects hepatic lipid metabolism in medaka, showing increased fatty acid accumulation and altered metabolic pathways.

A survey of public attitudes towards third-party reproduction in Japan in 2014

This study surveys public attitudes towards third-party reproduction and disclosure in Japan, finding that gender, age, and infertility experience influence opinions.