M. Nakayama

Interferon-α promotes neo-antigen formation andpreferential HLA-B-restricted antigen presentation in pancreatic β-cells

This study shows that IFN-α increases HLA-B-restricted antigen presentation in pancreatic β-cells, potentially influencing T1D pathogenesis.

A novel vaccine strategy using quick and easy conversion of bacterial pathogens to unnatural amino acid-auxotrophic suicide derivatives

This paper introduces a method to convert bacterial pathogens into live vaccines using unnatural amino acid-auxotrophic suicide derivatives, showing enhanced immunogenicity and safety.

qMaLioffG: A single green fluorescent protein FLIM indicator enabling quantitative imaging of endogenous ATP

The paper introduces qMaLioffG, a green fluorescent protein FLIM indicator that quantitatively measures endogenous ATP levels by detecting fluorescence lifetime changes in physiological ATP concentrations.

Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses

This study shows that Coxsackievirus B directly kills pancreatic β-cells and elicits weak CD8+ T-cell responses, suggesting vaccination could prevent type 1 diabetes.

Progressive spreading of DNA methylation in the GSTP1 promoter CpG island across transitions from precursors to invasive prostate cancer

The paper examines DNA methylation patterns in the GSTP1 promoter across prostate cancer progression stages and finds increasing methylation from normal to cancerous lesions.

Different Physical Parameters in the Bonds between Platelet Glycoprotein Ibalpha with von Willebrand factor and with Coagulant Factor XI -Results from the Molecular Dynamic Simulation-

This study uses molecular dynamics simulations to compare the physical stability and binding energy of VWF-GPIb and FXI-GPIb bonds, finding VWF-GPIb more stable with higher binding energy.

Fc-modified SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models.

The paper develops Fc-modified SARS-CoV-2 neutralizing antibodies effective against variants, showing reduced viral titers and lung damage in animal models.

An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants

This study develops a vaccinia-based vaccine encoding SARS-CoV-2 spike protein that induces broad and durable immunity, protecting against multiple variants in non-human primates and transgenic mice.

Basic reproduction numbers of three strains of mouse hepatitis viruses in mice

This study determines the basic reproduction numbers of three MHV strains in mice by analyzing antibody presence and viral distribution.

Optimization of an LNP-mRNA vaccine candidate targeting SARS-CoV-2 receptor-binding domain

This study optimizes an LNP-mRNA vaccine targeting SARS-CoV-2 RBD by removing reactogenic materials, improving immunogenicity and protection in macaques.

Multilevel modeling of cell population migration cycles and response to environmental pH in Bacillus subtilis

This study develops a multilevel mathematical model to simulate Bacillus subtilis cell population migration cycles and their response to environmental pH.

Neutralizing antibody-dependent and -independent immune responses against SARS-CoV-2 in cynomolgus macaques

This study examines immune responses in cynomolgus macaques infected with SARS-CoV-2, showing both neutralizing antibodies and IFN-γ-producing T-cells contribute to viral clearance.

Interleukin-11 is a Marker for Both Cancer- and Inflammation-Associated Fibroblasts that Contribute to Colorectal Cancer Progression

This study identifies IL-11 as a marker for fibroblasts involved in colorectal cancer progression, showing their role in tumor development through a feed-forward loop.

The somatically generated T cell receptor CDR3a contributes to the MHC allele specificity of the T cell receptor

The paper shows that the somatically generated CDR3a of T cell receptors influences MHC allele specificity during positive selection.