Author

J. Rocha-Pereira

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Organism:human· 2 Organism:rat· 2

Frequent Co-Authors

J. Neyts· 6 shared E. Heylen· 3 shared L. Delang· 3 shared S. ter Horst· 3 shared V. Vergote· 3 shared A. Cuvry· 2 shared B. Weynand· 2 shared C. De Keyzer· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersMicrobiology

J. Neyts

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Proliferative cell targeting and epithelial cell turnover fuels hepatitis E virus replication in human intestinal enteroids

N. Santos-Ferreira, X. Zhang, L. Corneillie, J. Van Dycke, W. Chiu, C. Montpellier, J. Neyts, L. Cocquerel, S. Kaptein, J. Rocha-Pereira

This study establishes an HEV-HIE model showing HEV replication in intestinal epithelial cells, with proliferative cells being the main targets, suggesting the gut as an HEV reservoir.

bioRxiv · Mar 27, 2024Microbiology

The dissemination of Rift Valley fever virus to the eye and sensory neurons of zebrafish larvae is stat1 dependent.

S. ter Horst, A. Siekierska, A.-S. De Meulemeester, A. Cuvry, L. Cools, J. Neyts, P. de Witte, J. Rocha-Pereira

This study shows that RVFV spreads to the eye and sensory neurons in zebrafish larvae in a stat1-dependent manner, causing blindness through direct damage rather than brain infection.

bioRxiv · Aug 10, 2022Microbiology

Human norovirus efficiently replicates in differentiated 3D-human intestinal enteroids

C. Mirabelli, N. Santos-Ferreira, M. G. Gillilland, R. J. Cieza, J. Colacino, J. Z. Sexton, S. Taube, J. Rocha-Pereira, C. E. Wobus

This paper develops a simplified protocol for infecting 3D-human intestinal enteroids with human norovirus, showing improved infection efficiency and host response analysis.

bioRxiv · Jun 9, 2022Microbiology

Nelfinavir markedly improves lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect

C. S. Foo, R. Abdelnabi, S. J. F. Kaptein, X. Zhang, S. ter Horst, R. Mols, L. Delang, J. Rocha-Pereira, L. Coelmont, P. Leyssen, K. Dallmeier, V. Vergote, E. Heylen, L. Vangeel, A. K. Chatterjee, , J. Neyts

Nelfinavir reduces SARS-CoV-2-induced lung pathology in Syrian hamsters without affecting viral RNA or infectious titers.

bioRxiv · Feb 1, 2021 · PreprintMicrobiology

Antiviral treatment of SARS-CoV-2-infected hamsters reveals a weak effect of favipiravir and a complete lack of effect for hydroxychloroquine

S. J. Kaptein, S. Jacobs, L. Langendries, L. Seldeslachts, S. ter Horst, L. Liesenborghs, B. Hens, V. Vergote, E. Heylen, E. Maas, C. De Keyzer, L. Bervoets, J. Rymenants, T. Van Buyten, H. J. Thibaut, , L. Delang

This study evaluates the antiviral effects of favipiravir and hydroxychloroquine in SARS-CoV-2-infected hamsters, finding limited efficacy for both drugs.

bioRxiv · Jun 19, 2020 · PreprintMicrobiology

STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

R. Boudewijns, H. J. Thibaut, S. J. F. Kaptein, R. Li, V. Vergote, L. Seldeslachts, C. De Keyzer, L. Bervoets, S. Sharma, J. Van Weyenbergh, L. Liesenborghs, J. Ma, S. Jansen, D. Van Looveren, T. Vercruysse, , X. Saelens

This study shows that STAT2 signaling both restricts SARS-CoV-2 spread and causes severe pneumonia in infected hamsters.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology

STAT1-dependent tolerance of intestinal viral infection

H. A. Filyk, A. J. Sharon, N. M. Fonseca, R. L. Simister, W. Yuen, B. K. Hardman, H. G. Robinson, J. H. Seo, J. Rocha-Pereira, I. Welch, J. Neyts, S. A. Crowe, L. C. Osborne

This study identifies STAT1 as a key regulator of intestinal tolerance to a commensal virus, showing it restricts viral replication and prevents tissue damage without requiring T cell responses.

bioRxiv · Feb 13, 2020 · PreprintImmunology

A robust human norovirus replication model in zebrafish larvae

J. Van Dycke, A. Ny, N. Conceicao-Neto, J. Maes, M. Hosmillo, A. Cuvry, I. Goodfellow, T. C. de Araujo Nogueira, E. Verbeken, J. Matthijnssens, P. de Witte, J. Neyts, J. Rocha-Pereira

This study establishes a zebrafish larval model for human norovirus replication, showing high viral titers and antiviral response potential.

bioRxiv · Jan 23, 2019Microbiology