A. Mironov

Pauperization of Emerin from nuclear envelope during chromatin bridge resolution drives prostate cancer cell migration and invasiveness

The paper shows that micronuclei formation during chromatin bridge resolution in prostate cancer cells leads to emerin pauperization from the nuclear envelope, enhancing cell migration and invasiveness.

Dual role of brain endothelial Gpr126 in blood-brain barrier development and ischemic stroke

This study identifies Gpr126 as a regulator of BBB development and shows its detrimental role in ischemic stroke, with potential therapeutic implications.

Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation

This study identifies integrin α6β4 and hemidesmosomes as critical for PDAC cell proliferation and ECM organization, with implications for therapeutic targeting.

A novel nanoluciferase transgenic reporter to measure proteinuria in zebrafish

This paper develops a transgenic zebrafish reporter to measure proteinuria, demonstrating its utility in detecting kidney disease models and drug responses.

Kidney organoids: A system to study human basement membrane assembly in health and disease

This study uses kidney organoids to investigate basement membrane assembly dynamics, identifying conserved temporal patterns and pathogenic variant effects.

Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1

This study identifies myosin VI as a regulator of ciliogenesis by controlling OFD1 localization and turnover, linking it to ciliopathies.

Large extracellular vesicles can be characterised by multiplex labelling using imaging flow cytometry

The paper develops a method to isolate and characterize large extracellular vesicles using imaging flow cytometry, showing a correlation between EV size and marker expression.

Uncoating of COPII from ER exit site membranes precedes cargo accumulation and membrane fission

The paper shows that COPII uncoating occurs before cargo accumulation and membrane fission during ER to Golgi transport.