R. Lorenzo-Redondo

TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo

TGF-β blockade with galunisertib reverses SIV latency, reduces viral reservoirs, and enhances immune responses in ART-treated macaques without systemic inflammation.

Temporal and spatial characterization of HIV/SIV infection at anorectal mucosa using rhesus macaque rectal challenge model

The study investigates HIV/SIV infection in rhesus macaques, identifying early infected cell types and tissue-specific changes in the anorectal mucosa.

Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo

This study shows that blocking TGF-β signaling increases HIV-1 and SIV reactivation and boosts immune responses in infected individuals on ART.

An immunoPET probe to SARS-CoV-2 reveals early infection of the male genital tract in rhesus macaques

This paper uses immunoPET to track SARS-CoV-2 infection in rhesus macaques, revealing infection of the male genital tract and differences in lung pathology between SARS-CoV-2 variants.

Localization of infection in neonatal rhesus macaques after oral viral challenge

This study uses PET and fluorescent microscopy to track HIV distribution in neonatal rhesus macaques after oral challenge, showing virions localize to the rectal mucosa by four hours and the intestine contains the most infected cells at 96 hours.