Author

C. M. Fennessey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:non-human primate· 2 Organism:rat· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. F. Keele· 4 shared J. D. Lifson· 3 shared D. H. O'Connor· 2 shared X. Alvarez· 2 shared A. A. Lackner· 1 shared A. G. Grandea· 1 shared A. M. Weiler· 1 shared A. O. Jordan· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersImmunology

B. F. Keele

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

M. W. Grunst, H. M. Gil, A. G. Grandea, B. J. Snow, R. Andrabi, R. Nedellec, I. Burton, N. M. Clark, S. K. Janaka, N. K. Keles, R. V. Moriarty, A. M. Weiler, S. Capuano, C. M. Fennessey, T. C. Friedrich, , D. T. Evans

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

bioRxiv · Nov 14, 2023Microbiology

TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo

J. Kime, D. Bose, M. Arainga, M. R. Haque, C. M. Fennessey, R. A. Caddell, Y. Thomas, D. E. Ferrell, S. Ali, E. Grody, Y. Goyal, C. Cicala, J. Arthos, B. F. Keele, M. Vaccari, , E. Marinelli

TGF-β blockade with galunisertib reverses SIV latency, reduces viral reservoirs, and enhances immune responses in ART-treated macaques without systemic inflammation.

bioRxiv · Sep 5, 2023Immunology

Lymphoid tissues contribute to viral clonotypes present in plasma at early post-ATI in SIV-infected rhesus macaques

A. Solis-Leal, N. Boby, S. Mallick, Y. Cheng, F. Wu, G. De La Torre, J. Dufour, X. Alvarez, V. Shivanna, Y. Liu, C. M. Fennessey, J. D. Lifson, Q. Li, B. F. Keele, B. Ling

This study identifies secondary lymphoid tissues as a source of SIV clonotypes detected in plasma early after antiretroviral therapy interruption.

bioRxiv · May 30, 2023 · PreprintImmunology

A tyrosine-based trafficking signal in the simian immunodeficiency virus envelope cytoplasmic domain is strongly selected for in pathogenic SIV infection

S. Lawrence, S. E. Elser, W. Torben, R. V. Blair, B. Pahar, P. P. Aye, F. Schiro, D. Szeltner, L. A. Doyle-Meyers, B. Haggarty, A. O. Jordan, J. Romano, X. Alvarez, D. H. O'Connor, R. W. Wiseman, , J. A. Hoxie

This study shows that a tyrosine-based trafficking signal in SIV Env is strongly selected for during pathogenic infection, as mutations reconstitute endocytosis and polarized sorting signals.

bioRxiv · Mar 31, 2021 · PreprintCell Biology