Author

T. Carvalho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 3 Immunology· 2 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Research Focus:cell type annotation· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Assay:proteomics· 3 Organism:human· 2 Assay:metagenomics· 2

Frequent Co-Authors

C. C. Faria· 2 shared C. Custodia· 2 shared E. Paisana· 2 shared J. Hite· 2 shared J. Miguens· 2 shared J. Pimentel· 2 shared J. T. Barata· 2 shared L. F. Toledo· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

C. C. Faria

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10 papers

Recent·Most cited

Global trends in antimicrobial resistance on organic and conventional farms

E. Ager, T. Carvalho, E. Silva, S. Ricke, J. Hite

This study examines whether organic farming reduces antimicrobial resistance in livestock and finds it reduces AMR prevalence by 26.9-42.9% across different species and environments.

Scientific Reports · Dec 18, 2023Peer-reviewedMicrobiology

Byproducts of inflammatory radical metabolism provide transient nutrient niches for microbes in the inflamed gut

L. Spiga, M. G. Winter, M. Muramatsu, V. Rojas, R. Chanin, W. Zhu, E. R. Hughes, S. Taylor, F. Faber, S. Porwollik, T. Carvalho, T. Qin, R. Santos, H. L. Andrews-Polymenis, M. McClelland, S. E. Winter

The paper investigates how inflammatory radicals generate tartaric acid isomers, which serve as transient nutrients for gut pathogens in murine models.

bioRxiv · Dec 8, 2023 · PreprintMicrobiology

Absence of Telomerase Leads to Immune Response and Tumor Regression in Zebrafish Melanoma

B. Lopes-Bastos, J. Nabais, T. Ferreira, M. El-Mai, M. Bird, S. Targen, D. Kang, J.-X. Yue, T. Carvalho, M. G. Ferreira

This study shows that telomerase absence in zebrafish melanoma leads to tumor regression via immune response and cell cycle arrest, despite initial tumor formation.

bioRxiv · Mar 24, 2023Cancer Biology

Discovery of an endogenous DNA virus in the amphibian killing fungus and its association with pathogen genotype and virulence

R. Clemons, M. Yacoub, E. Faust, L. F. Toledo, T. S. Jenkinson, T. Carvalho, D. R. Simmons, E. Kalinka, L. K. Fritz-Laylin, T. Y. James, J. E. Stajich

The paper identifies a DNA virus in the amphibian-killing fungus Bd and links its presence to reduced host growth and increased virulence.

bioRxiv · Mar 16, 2023 · PreprintMicrobiology

UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease

E. Paisana, R. Cascao, C. Custodia, N. Qin, D. Picard, D. Pauck, T. Carvalho, P. Ruivo, C. Barreto, D. Doutel, J. Cabecadas, R. Roque, J. Pimentel, J. Miguens, J. T. Barata, C. C. Faria

This study identifies UBE2C as a driver of leptomeningeal dissemination in brain metastases and shows that PI3K/mTOR inhibition can prevent its metastatic effects.

bioRxiv · Oct 4, 2022 · PreprintCancer Biology

Coinfection with chytrid genotypes drives divergent infection dynamics reflecting broad epidemiological patterns

T. Carvalho, D. Medina, L. P. Ribeiro, D. Rodriguez, T. S. Jenkinson, G. Becker, L. F. Toledo, J. Hite

The paper investigates how coinfection with different chytrid genotypes affects virulence and transmission, finding that coinfection can increase virulence in less competitive genotypes and favor more virulent panzootic genotypes.

bioRxiv · Sep 28, 2022Ecology

Maternal γδ T Cells Shape Offspring Pulmonary Type-2 Immunity In A Microbiota-Dependent Manner

P. H. Papotto, B. Yilmaz, G. Pimenta, S. Mensurado, C. Cunha, G. J. Fiala, D. Gomes da Costa, N. Goncalves-Sousa, B. H. K. Chan, B. Blankenhaus, T. Carvalho, A. J. Macpherson, J. E. Allen, B. Silva-Santos

This study shows maternal γδ T cells influence offspring pulmonary type-2 immunity through microbiota-dependent mechanisms, affecting gut-lung axis development and inflammation.

bioRxiv · Aug 13, 2021Immunology

Patient-derived models of brain metastases recapitulate the histopathology and biology of human metastatic cancers

C. C. Faria, C. Custodia, R. Cascao, E. Paisana, T. Carvalho, P. Pereira, R. Roque, J. Pimentel, J. Miguens, J. T. Barata

This study develops patient-derived xenograft models of brain metastases that replicate human cancer biology and respond to targeted therapies.

bioRxiv · Nov 26, 2020 · PreprintCancer Biology

First description of a herpesvirus infection in genus Lepus

F. A. Abade dos Santos, M. Monteiro, A. Pinto, C. L. Carvalho, M. C. Peleteiro, P. Carvalho, P. Mendonca, T. Carvalho, M. D. Duarte

The paper describes the first identification of a herpesvirus in Iberian hares, which circulates asymptotically and is phylogenetically related to bat and rodent herpesviruses.

PLOS ONE · Apr 17, 2020Peer-reviewedMicrobiology

Light-entrained and brain-tuned circadian circuits regulate ILC3 and gut homeostasis

C. Godinho-Silva, R. G. Domingues, M. Rendas, B. Raposo, H. Ribeiro, J. Alves da Silva, A. Vieira, R. M. Costa, N. L. Barbosa-Morais, T. Carvalho, H. Veiga-Fernandes

This study shows that circadian circuits regulated by light and the brain control ILC3 function, gut homeostasis, and metabolism.

bioRxiv · Aug 27, 2019Immunology