Author

D. Barkley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

I. Yanai· 3 shared M. Baron· 3 shared A. Rao· 2 shared B. Xia· 2 shared G. S. Franca· 2 shared M. Pour· 2 shared A. Lund· 1 shared A. Patel· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

I. Yanai

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Drug-induced adaptation along a resistance continuum in cancer cells

G. S. Franca, M. Baron, M. Pour, B. R. King, A. Rao, S. Misirlioglu, D. Barkley, I. Dolgalev, K. Ho-Tang, G. Avital, F. Kuperwaser, A. Patel, D. A. Levine, T. Lionnet, I. Yanai

This study shows that gradual dose exposure and prolonged treatment drive ovarian cancer cell resistance to targeted therapy through a continuous adaptation process involving transcriptional, epigenetic, and genetic changes.

bioRxiv · Jun 21, 2022Cancer Biology

Recurrence of cancer cell states across diverse tumors and their interactions with the microenvironment

D. Barkley, R. Moncada, M. Pour, D. Liberman, I. Dryg, G. Werba, W. Wang, M. Baron, A. Rao, B. Xia, G. S. Franca, A. Weil, D. F. Delair, C. Hajdu, A. Lund, , I. Yanai

The paper identifies recurrent cancer cell states across 15 tumor types and examines their interactions with the tumor microenvironment using single-cell RNA-Seq and spatial transcriptomics.

bioRxiv · Dec 20, 2021 · PreprintCancer Biology

Widespread transcriptional scanning in the testis modulates gene evolution rates

B. Xia, Y. Yan, M. Baron, F. Wagner, D. Barkley, M. Chiodin, S. Y. Kim, D. L. Keefe, J. P. Alukal, J. D. Boeke, I. Yanai

The paper maps gene expression in human spermatogenesis and finds that expressed genes have fewer germline mutations, suggesting transcriptional scanning reduces DNA damage and influences gene evolution rates.

bioRxiv · Jan 22, 2019Evolutionary Biology